In 1999 the Nobel Prize in Physiology or Medicine was awarded to Gunter Blobel for the discovery that proteins have intrinsic signals that govern their transport and localisation in the cell. It was based on this research into how cells use these signals that the functions of glycoproteins were discovered.
Glycoproteins are molecules that have a sugars and protein bonded together. The sugar chains of glycoproteins play a role in determining their destination in the cell or body. The bonding of sugars to proteins to form glycoproteins significantly alters the properties of these proteins.
There are eight sugars that predominantly bond with proteins to form glycoproteins, these are: xylose, galactose, glucose, mannose, fucose, N-acetylgalactosamine, N-acetylglucosamine and N-acetylneuraminic acid.
WHAT ARE THE FUNCTIONS OF GLYCOPROTEINS?
Glycans contain biologic information and are the specific sequence of sugars in a glycoprotein that determine its recognition and interaction with other molecules in the … Read More