o Nasopharyngeal carcinoma (NPC) is endemic in certain parts of Asia, such as Southern China, but occurs sporadically in the Western world
o At Dr. Cipto Mangunkusumo Hospital, Jakarta, there are 90-120 new cases each year
o NPC is sensitive to both radiotherapy and chemotherapy (the first line treatment for NPC is irradiation)
o Several therapeutic modalities have been used in recurrent NPC including external irradiation, brachytherapy, chemotherapy, neck dissection, and combinations of those treatment. Serious side effects are seen following re-irradiation
o Foscan (mTHPC, meta-tetrahydroxyphenilchlorin, temorphfin) is a second-generation photosensitizer which is activated by red light (652nm).
o It is a purified synthetic compound with a photophysical efficiency that allows short treatment times (typically 100 to 300 seconds), using small drug dosages
o The period of skin photosensitivity is approximately 2 weeks following injection of Foscan
o Photodynamic therapy is a therapeutical concept based on the … Read More